论文部分内容阅读
卡莫氟（ＨＣＦＵ）是５－氟尿嘧啶的衍生物。在本实验中每日以ＨＣＦＵ１００ｍｇ／ｋｇ灌胃，共７天，对小鼠Ｓ１８０和Ｌｅｗｉｓ肺癌的抑制率分别为８２％和４９％。它亦减少小鼠艾氏腹水癌（ＥＡＣ）的腹水生成及癌细胞数。在用二甲肼诱发的小鼠大肠癌模型上，ＨＣＦＵ明显减少大肠肿瘤的发生，抑瘤率为７６％。应用３Ｈ－ＴｄＲ和３Ｈ－Ｕｒｄ同位素掺入法显示本药可显著抑制ＥＡＣ癌细胞ＤＮＡ和ＲＮＡ的合成，用显微分光光度计测量单个ＥＡＣ细胞的ＤＮＡ含量，亦证实ＨＣＦＵ具有抑制ＤＮＡ合成的作用。
Carmofur (HCFU) is a derivative of 5-fluorouracil. In this experiment daily HCFU100mg / kg gavage, a total of 7 days, the inhibition rate of mice S180 and Lewis lung cancer were 82% and 49%. It also reduces ascites formation and cancer cells in Ehrlich ascites carcinoma (EAC) in mice. In the model of mouse colorectal cancer induced by dimethylhydrazine, HCFU significantly reduced the incidence of colorectal cancer with a tumor inhibition rate of 76%. 3H-TdR and 3H-Urd isotope incorporation showed that the drug significantly inhibited the DNA and RNA synthesis of EAC cancer cells. The DNA content of individual EAC cells was measured by a spectrophotometer. HCFU was also found to inhibit the DNA synthesis .