磺胺引起肝脏的不良反应是少见的,本文报告4例因反复尿路感染使用磺胺(Sulfapral 2片,每日2次)治疗,多次发作黄疸。病人均为女性,年龄20、30、35及68岁,既往曾因使用磺胺引起肝脏不良反应,8例发生过1次,1例2次,当再次使用该药作第3～5次疗程时均引起黄疸发作,第1次黄疸发生于磺胺治疗期2～9周(平均5周),第2次发作于使用后1～2周(平均1.5周),第3次平均仅1周 Sulfanilamide caused adverse reactions in the liver is rare, the paper reported 4 cases of recurrent urinary tract infection with sulfa (Sulfapral 2 tablets twice daily) treatment, multiple attacks of jaundice. Patients were female, aged 20, 30, 35 and 68 years old, had previously caused by the use of sulfonamides liver adverse reactions occurred in 8 cases 1, 2 cases in 1 case, when the drug is used again for the first 3 to 5 courses All caused jaundice attack. The first jaundice occurred in the period of 2 to 9 weeks (mean 5 weeks) in the sulfa therapy period, the second attack was in 1 to 2 weeks (average 1.5 weeks) after use, the third average only 1 week