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结核分枝杆菌(mycobacterium tuberculosis,MTB)是一种能够引起结核病的病原菌,除了能够引起常见的肺结核外,还能够侵犯全身多个器官引起相应结核病。肺结核病是由结核分枝杆菌引起的呼吸系统传染病,人感染结核分枝杆菌后是否发病与免疫功能密切相关~([1])。目前结核病的诊断和治疗面临着巨大挑战,尤其是难治性结核病及耐药结核病的诊断及有效治疗问题~([2])。自20世纪80年代,
Mycobacterium tuberculosis (MTB) is a pathogenic bacterium that causes tuberculosis. In addition to causing common tuberculosis, MTB can invade multiple organs of the body to cause tuberculosis. Pulmonary tuberculosis is a respiratory system caused by Mycobacterium tuberculosis. It is closely related to the immune function of human infected with Mycobacterium tuberculosis ([1]). At present, the diagnosis and treatment of tuberculosis are facing great challenges, especially the diagnosis and effective treatment of refractory tuberculosis and drug-resistant tuberculosis [2]. Since the 1980s,