糖基化终末产物是体内蛋白质与葡萄糖或其他还原单糖反应生成的稳定的共价化合物 ,它可通过损伤血管内皮、促进白细胞粘附、增加血小板聚集和刺激血管平滑肌增殖等机制 ,促进动脉粥样硬化、糖尿病血管并发症、尿毒症以及血管性勃起功能障碍等疾病的发生发展。因此 ,寻找或开发抑制糖基化终末产物形成和作用的抑制药对预防和治疗血管疾病有着重要的意义。 Glycation end products are stable covalent compounds produced by the reaction of proteins with glucose or other reducing monosaccharides. They promote the arteries through mechanisms such as damaging the vascular endothelium, promoting leukocyte adhesion, increasing platelet aggregation and stimulating vascular smooth muscle proliferation Atherosclerosis, diabetic vascular complications, uremia and vascular erectile dysfunction and other diseases. Therefore, finding or developing inhibitors that inhibit the formation and action of advanced glycation end products is of great importance for the prevention and treatment of vascular diseases.