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据报道在EAE小鼠脑脊髓炎T细胞对髓鞘碱性蛋白(MBP)的应答中,T细胞受体Vβ8.2(TcrbV8.2)基因片段呈优势表达。该作者以往的研究已证实了EAE小鼠的蜗后性听力损失。给予特异性T细胞受体Vβ8(TcrbV8)亚型的单克隆抗体可以预防这种类型的听力损失及中枢神经疾病。此研究旨在检测Tc
It has been reported that the T cell receptor Vβ8.2 (TcrbV8.2) gene fragment is predominantly expressed in response to myelin basic protein (MBP) in EAE mouse encephalomyelitis T cells. Previous studies by this author have confirmed the retrograde hearing loss in EAE mice. Monoclonal antibodies administered to a subtype of the specific T cell receptor Vβ8 (TcrbV8) can prevent this type of hearing loss and central nervous system disorders. This study aimed to detect Tc