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目的:探讨格列齐特缓释片联合基础胰岛素在磺脲类继发失效的2型糖尿病治疗中临床疗效。方法:将在我院经治的78例糖尿病患者,均为磺脲类继发失效的2型糖尿病病例,均使用格列齐特缓释片联合基础胰岛素治疗,观察治疗后的临床疗效。结果:患者在治疗后的空腹血糖、餐后2小时血糖、糖化血红蛋白的浓度较治疗前明显降低,差异具有显著性(P<0.05)。结论:列齐特缓释片联合基础胰岛素应用于磺脲类继发失效的2型糖尿病治疗是一种有效的治疗方法,疗效确切。
Objective: To investigate the clinical efficacy of gliclazide combined with basal insulin in the treatment of type 2 diabetes mellitus secondary to failure of sulfonylureas. Methods: 78 cases of diabetic patients who were treated in our hospital were all type 2 diabetic patients with secondary failure of sulfonylureas. Gliclazide sustained-release tablets combined with basal insulin therapy were used to observe the clinical effect after treatment. Results: The fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin in patients after treatment were significantly lower than those before treatment, the difference was significant (P <0.05). CONCLUSION: The combination of levodile sustained-release tablets and basal insulin in the treatment of type 2 diabetes mellitus secondary to sulfonylurea failure is an effective treatment method with definite curative effect.