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目的·探讨深圳地区妊娠期糖尿病(GDM)的危险因素。方法·选择2014年2月—2015年7月深圳地区住院待产的432例GDM患者及409例正常血糖(NGT)孕妇,收集孕妇资料,检测孕妇孕早期空腹血糖及糖化血红蛋白、孕24~28周口服葡萄糖耐量试验(OGTT),采用Logistic回归分析法探讨GDM的危险因素。结果·GDM组的年龄、孕前体质量、孕前BM高于NGT组(均P=0.000),2组分娩前体质量和分娩前BM差异无统计学意义。Logistic单因素分析显示,2组在既往GDM史、孕前超重(BMI≥25 kg/m~2)、糖尿病家族史、高龄(年龄≥35岁)方面比较,差异具有统计学意义;进一步采用Logistic多因素分析显示,既往GDM史、孕前超重、糖尿病家族史、高龄是GDM的危险因素(均P<0.05)。结论·既往GDM史、孕前超重、糖尿病家族史、高龄是GDM的危险因素。
Objective To explore the risk factors of gestational diabetes mellitus (GDM) in Shenzhen. Methods · Select 432 pregnant women and 409 normal blood glucose (NGT) pregnant women in hospital from February 2014 to July 2015 in Shenzhen. Data of pregnant women were collected to detect fasting blood glucose and glycosylated hemoglobin in the first trimester of pregnancy. Oral glucose tolerance test (OGTT), using Logistic regression analysis of risk factors for GDM. Results · There was no significant difference in the age, pre-pregnant body weight, BM before pregnancy in the GDM group and NGT group (both P = 0.000). Logistic univariate analysis showed that there was significant difference between the two groups in previous GDM history, pre-pregnancy overweight (BMI≥25 kg / m ~ 2), family history of diabetes, and advanced age (≥35 years old) Factor analysis showed that the past GDM history, pre-pregnancy overweight, family history of diabetes, and advanced age were risk factors of GDM (all P <0.05). Conclusion · Previous GDM history, pre-pregnancy overweight, family history of diabetes, and advanced age are risk factors for GDM.