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目的探讨诱发排卵的门诊患者人绒毛膜促性腺激素(human chorionic,gonadotropin,HCG)日血清白细胞介素-6(interleukin,IL-6)对卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)发生的预测价值。方法根据是否发生OHSS将165例患者分为两组,OHSS组23例,非OHSS组142例,分别检测诱发排卵周期中HCG日血清雌二醇(estradiol,E2)、IL-6水平及≥14 mm卵泡数,进行对比分析,并采用ROC曲线分别评价三者对OHSS发生的预测价值。结果 OHSS组患者HCG日血清IL-6、E2水平和≥14 mm卵泡数显著高于非OHSS组(P<0.05),分别为(187.0±34.6 vs 110.5±30.0)pg/mL、(1 563.5±626.0 vs 587.1±384.6)pg/mL、(5.0±1.4 vs 1.7±0.9)个。ROC曲线分析结果显示ROC曲线下面积IL-6为0.951(95%CI:0.895~1.006,P<0.001);E2为0.913(95%CI:0.860~0.9660,P<0.001);≥14 mm卵泡数为0.974(95%CI:0.943~1.004,P<0.001)。结论在诱发排卵的不孕患者中,HCG日血清IL-6的水平也可用于预测OHSS的发生。
Objective To investigate the effect of serum interleukin (IL-6) on the development of ovarian hyperstimulation syndrome (OHSS) induced by ovarian gout in human chorionic gonadotropin (HCG) Predicted value. Methods Totally 165 patients were divided into two groups according to whether OHSS occurred or not. Twenty-three patients in OHSS group and 142 non-OHSS patients were enrolled in this study. Serum estradiol (E2), IL-6 levels and ≥14 mm follicles were analyzed and compared. The ROC curves were used to evaluate the predictive value of OHSS. Results Serum levels of IL-6, E2 and ≥ 14 mm follicles were significantly higher in OHSS group than those in non-OHSS group (187.0 ± 34.6 vs 110.5 ± 30.0, pg / mL, and (5643.5 ± 626.0 vs 587.1 ± 384.6) pg / mL, (5.0 ± 1.4 vs 1.7 ± 0.9). The ROC curve analysis showed that the area under the ROC curve was 0.951 (95% CI: 0.895-1.006, P <0.001), the area under the ROC curve was 0.913 (95% CI: 0.860-0.9660, P <0.001) Was 0.974 (95% CI: 0.943-1.004, P <0.001). Conclusions In infertile patients who induce ovulation, the level of serum IL-6 on HCG day can also be used to predict the occurrence of OHSS.