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目前糖尿病和脂肪肝的发病呈全球流行的趋势,且逐年递增,而2型糖尿病(T2DM)人群中非酒精性脂肪性肝病(NAFLD)的发病率明显高于正常人群。高脂高热量饮食、多坐少动的生活方式、胰岛素抵抗、2型糖尿病、代谢综合征等都是增加NAFLD发病的危险因素。胰岛素抵抗被认为是T2DM和NAFLD共同的病理生理学基础。肿瘤坏死因子、抵抗素、脂联素、瘦素、网膜素、内脏脂联素等细胞因子参与胰岛素抵抗,并在T2DM和NAFLD的发生发展中起重要作用。控制体质量、健康饮食、改善胰岛素抵抗是治疗NAFLD的原则,控制体重作为治疗原则的首选。
At present, the incidence of diabetes and fatty liver is a trend of global epidemic, and it is increasing year by year. However, the incidence of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes is significantly higher than that of normal people. High-fat high-calorie diet, sitting less sedentary lifestyle, insulin resistance, type 2 diabetes, metabolic syndrome are all risk factors to increase the incidence of NAFLD. Insulin resistance is thought to be the common pathophysiological basis of T2DM and NAFLD. Tumor necrosis factor, resistin, adiponectin, leptin, retinal, visceral adiponectin and other cytokines are involved in insulin resistance and play an important role in the occurrence and development of T2DM and NAFLD. Control of body weight, healthy diet, and improvement of insulin resistance are the principles of treatment of NAFLD, weight control as the preferred treatment principle.