两种苯丙烯酸类丹皮酚酯抗辐射作用初探

来源 :国际放射医学核医学杂志 | 被引量 : 0次 | 上传用户:leng36318
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目的 观察两种苯丙烯酸类丹皮酚酯化合物-4-甲基苯丙烯酸丹皮酚酯和4-氟苯丙烯酸丹皮酚酯的抗辐射作用.方法 以ICR小鼠为研究对象,通过相关脏器系数、白细胞数、血小板数、股骨有核细胞数和股骨骨髓DNA含量等指标,考察两个目标化合物低、中、高剂量下的抗辐射损伤效应.结果 与空白对照组比较,4-甲基苯丙烯酸丹皮酚酯和4-氟苯丙烯酸丹皮酚酯均可以提高受照小鼠的骨髓DNA含量和脾结节数、增大脾系数和胸腺系数,并使血小板数得到一定的恢复.结论 4-甲基苯丙烯酸丹皮酚酯和4-氟苯丙烯酸丹皮酚酯对小鼠辐射损伤具有一定的保护作用。

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