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近20年的流行病学研究表明,白念珠菌已成为第4位最常见的医院血流感染的病原菌。虽然对感染危险因素的认识以及感染的预防已取得长足进展,但念珠菌血症相关住院率和病死率仍呈上升趋势。侵袭性念珠菌病的病死率接近50%。虽然有许多抗真菌药物可供选择,但最佳治疗方案仍未达成共识。本文对各项临床研究中患者的个体资料进行分析,探讨不同治疗方案对念珠菌血症患者及其他侵袭性念珠菌病患者预后的影响。
Nearly 20 years of epidemiological studies have shown that Candida albicans has become the fourth most common hospital bloodstream infection pathogens. Although considerable progress has been made in understanding the risk factors for infection and in preventing infection, the rates of hospitalizations and mortality associated with candidaemia are still on the rise. The prevalence of invasive candidiasis is nearly 50%. Although many antifungal agents are available, the best treatment options have yet to reach consensus. This article analyzes the individual data of patients in various clinical studies to investigate the impact of different treatment options on the prognosis of patients with Candidemia and other invasive candidiasis.