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为了从吡唑类化合物中寻找具有新的活性物质,利用亚结构拼接原理,设计合成了一系列新型含取代异噁唑结构的吡唑酰胺类衍生物.利用1H NMR、13C NMR和元素分析对标题化合物的结构进行了表征.初步的生物活性测试结果表明,部分目标化合物具有较好的杀虫活性.在测试浓度为500μg/m L时,部分化合物对粘虫的防效为60%~100%,对蚜虫的杀死率分别为50%~100%.另外,部分化合物对Hep G2细胞显示出较好的抗肿瘤活性,其IC50值为14.2~18.9μmol/L.
In order to find novel active substances from pyrazole compounds, a series of novel pyrazole amide derivatives containing substituted isoxazole structures were designed and synthesized by using the substructure splicing principle.H NMR, 13C NMR and elemental analysis The structure of the title compound was characterized.The preliminary bioassay results showed that some of the target compounds had good insecticidal activity.At the test concentration of 500μg / m L, some of the compounds against armyworms 60% -100 %, Killing aphids were 50% to 100%. In addition, some compounds showed good antitumor activity on Hep G2 cells, the IC50 value of 14.2 ~ 18.9μmol / L.