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目的观察神经节苷酯治疗新生儿缺氧缺血性脑病(HIE)的疗效,探讨其临床应用价值。方法选取本院72例新生儿缺氧缺血性脑病患儿,随机分为2组,对照组(n=36)给予常规综合治疗,观察组(n=36)在综合治疗基础上给予神经节苷酯静脉滴注,对比两者患儿的临床疗效。结果观察组21例患儿治疗显效,13例治疗有效,总有效率94.4%,对照组治疗显效15例,有效13例,总有效率77.8%,两组差异有显著性(P<0.05);观察组治疗显效、有效患儿的临床症状平均消失时间明显短于对照组患儿,差异有显著性(P<0.05)。结论神经节苷酯辅助治疗新生儿缺氧缺血性脑病具有良好的疗效,可缩短患儿症状改善的时间,缩短疗程同时提高治愈率,具有临床推广意义。
Objective To observe the efficacy of ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and explore its clinical value. Methods Seventy-two neonates with hypoxic-ischemic encephalopathy were selected and randomly divided into two groups. The control group (n = 36) was given conventional therapy. The observation group (n = 36) was given the ganglion Glycosides intravenous infusion, compared with the clinical efficacy of both children. Results In the observation group, 21 cases were treated effectively, 13 cases were effective and the total effective rate was 94.4%. In the control group, 15 cases were effective and 13 cases were effective. The total effective rate was 77.8%. There was significant difference between the two groups (P <0.05). The treatment group was effective in observation group, and the average disappearance time of clinical symptoms in effective children was significantly shorter than that in control group (P <0.05). Conclusion Ganglioside adjuvant treatment of neonatal hypoxic-ischemic encephalopathy has a good effect, can shorten the time to improve the symptoms of children, shorten the course of treatment while improving the cure rate, with clinical significance.