目的对力生长因子(mechano-growth factor,MGF)的表达以及在组织修复与再生中的作用进行综述。方法广泛查阅近年来国内外有关MGF表达和参与组织修复与再生的文献,对其研究进展进行综述。结果 MGF在多种组织/细胞中表达,具有力敏感性,并能激活卫星细胞,促进成肌细胞增殖,在治疗肌肉缺损、预防心肌损伤和修复受损神经等方面起重要作用。结论 MGF在多种组织中的修复作用已明确,但其具体作用机制尚未明确,有待进一步深入研究。 Objective To review the expression of mechano-growth factor (MGF) and its role in tissue repair and regeneration. Methods The literatures about the expression of MGF and its involvement in tissue repair and regeneration in recent years are widely reviewed and reviewed. Results MGF was expressed in many tissues / cells with force sensitivity and could activate satellite cells and promote the proliferation of myoblasts. MGF plays an important role in the treatment of muscle defects, prevention of myocardial injury and repair of damaged nerves. Conclusion The repair effect of MGF in many tissues has been clarified, but the specific mechanism of action of MGF is not clear yet and needs further study.