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目的:探讨血小板及凝血相关指标是否可作为急性胰腺炎病情严重度的早期识别指标。方法:本研究共纳入2017年—2018年北京友谊医院收治的142例急性胰腺炎患者。根据Ranson评分分为轻症组及重症组。以重度胰腺炎作为结局指标，分别对轻度及重度患者间差异有统计学意义的单一指标进行单因素logistic回归分析及ROC曲线分析，判断其对疾病严重程度的区分价值。结果:根据Ranson评分将142例患者分为重症及轻症两组，重症患者43例，轻症患者99例。两组患者入院第一天血小板(PLT)、纤维蛋白原(FIB)、D-二聚体(D-Dimer)比较差异有统计学意义(n P<0.05)。对上述单一指标进行单因素logistic回归分析及ROC曲线分析，PLT、FIB、D-Dimer ROC曲线下面积及其95%n CI分别为0.61(0.52，0.71)、0.70(0.59，0.80)、0.72(0.62，0.82)。对PLT、FIB及D-Dimer拟合不同指标联合的多因素logistic回归模型，并进行ROC曲线分析，PLT联合D-Dimer的ROC曲线下面积为0.74(0.65，0.83)，FIB联合D-Dimer的曲线下面积为0.75(0.66，0.85)。n 结论:PLT、FIB及D-Dimer可作为判断急性胰腺炎病情严重度的独立危险因素，FIB联合D-Dimer对病情严重度的早期预警高于PLT联合D-Dimer对病情严重度的预警价值。“,”Objective:To investigate whether platelet and coagulation-related indicators can be used as early indicators of severity of acute pancreatitis.Methods:A total of 142 patients with acute pancreatitis admitted to Beijing Friendship Hospital from 2017 to 2018 were included in this study. According to the Ranson score, they were divided into mild group and severe group. Severe pancreatitis was used as the outcome index. Univariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were performed on single indicators with statistically significant differences between mild and severe patients to determine the discriminative value of disease severity.Results:According to the Ranson score, 142 patients were divided into severe and mild groups, 43 patients with severe disease, and 99 patients with mild disease. There was a statistically significant difference in platelet, fibrinogen (FIB), and D-Dimer between the two groups on the first day of admission (n P<0.05). The area under ROC curve and 95%n CI of platelets (PLT) , FIB and D-Dimer were 0.61 (0.52, 0.71), 0.70 (0.59, 0.80) and 0.72 (0.62, 0.82), respectively. Multivariate logistic regression models of PLT, FIB and D-Dimer were fitted, and ROC curve was analyzed. The area of ROC curve of PLT combined with D-Dimer was 0.74 (0.65, 0.83), and the area of ROC curve of FIB combined with D-Dimer was 0.75 (0.66, 0.85).n Conclusions:Platelet, FIB and D-Dimer can be used as independent risk factors to judge the severity of pancreatitis. The early predicative value of FIB combined with D-Dimer on the severity of the disease is higher than that of the PLT combined with D-Dimer.