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目的探讨人表皮生长因子受体2(HER-2)蛋白在胃癌组织中的表达及病理价值。方法检测300例胃癌患者的胃癌和癌旁胃组织的HER-2蛋白表达,分析HER-2表达量与胃癌临床病理参数的关系。结果 HER-2蛋白只在胃癌组织中表达,在癌旁组织中并无表达。胃癌组织中,免疫组化染色强阳性HER-2和中等阳性HER-2的表达率分别为15%和6%;HER-2阳性表达和胃癌是否远处转移、分期和脉管神经受累有关(P<0.05)。HER-2阳性表达和患者的淋巴结转移、肿瘤部位及其浸润深度无关(P>0.05)。结论 HER-2蛋白在胃癌组织中高表达,与胃癌的生物学行为密切相关,可为胃癌的靶向治疗提供参考。
Objective To investigate the expression of human epidermal growth factor receptor 2 (HER-2) protein in gastric carcinoma and its pathological value. Methods The HER-2 protein expression in gastric cancer and adjacent gastric tissue in 300 gastric cancer patients was detected. The relationship between HER-2 expression and clinical pathological parameters of gastric cancer was analyzed. Results The HER-2 protein was only expressed in gastric cancer tissues but not in paracancerous tissues. The positive rates of HER-2 and moderate-positive HER-2 expression in gastric cancer tissues were 15% and 6%, respectively. The positive expression of HER-2 was related to the distant metastasis of gastric cancer, the stage and the involvement of vascular nerves P <0.05). The positive expression of HER-2 was not associated with lymph node metastasis, tumor location and depth of invasion (P> 0.05). Conclusion The high expression of HER-2 protein in gastric cancer tissue is closely related to the biological behavior of gastric cancer, which may provide a reference for the targeted therapy of gastric cancer.