肿瘤坏死因子-α(TNF-α)是主要由单核细胞或巨噬细胞产生的多功能蛋白质。用真核细胞系中异原性表达的高纯化物质检测其在体内外活性,发现有刺激血管生成、调常MHC 抗原表达和抑制脂肪细胞分化及功能等多种功能,并指出 TNF-α是巨噬细胞介导肿瘤细胞毒性的重要效应分子。Le 等曾对这些特 Tumor necrosis factor-α (TNF-α) is a multifunctional protein mainly produced by monocytes or macrophages. The in vitro and in vivo activities of highly purified substances expressed exogenously in eukaryotic cell lines were examined and found to stimulate angiogenesis, regulate MHC antigen expression and inhibit adipocyte differentiation and function, and pointed out that TNF-α is Macrophage-mediated important effector molecules for tumor cell toxicity. Le et al.