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以孕烯醇酮为原料,通过17-位甲基酮与不同的芳香醛反应生成α,β-不饱和酮,再与水合肼反应得到具有吡唑啉结构的甾体芳杂环化合物;采用MTT法测试目标物对3种肿瘤细胞株的体外抗肿瘤活性。结果表明,4个目标物对人体结肠癌细胞HT-29、宫颈癌细胞He La和胃癌细胞SGC-7901均表现出很好的生长抑制活性,而且对宫颈癌细胞He La的抑制活性优于阳性对照药顺铂。
Taking pregnenolone as raw material, α-β-unsaturated ketone is formed by reaction of 17-methyl ketone with different aromatic aldehydes and then reacted with hydrazine hydrate to obtain a steroid aromatic heterocyclic compound with pyrazoline structure; In vitro antitumor activity of the target against three tumor cell lines by MTT method. The results showed that the four targets showed good growth inhibitory activity on human colon cancer cells HT-29, cervical cancer cells He La and gastric cancer cells SGC-7901, and had better inhibitory activity on He La of cervical cancer cells than positive ones Control drug cisplatin.