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目的观察药用炭片胃管注入加保留灌肠治疗有机磷中毒的疗效。方法回顾分析66例有机磷中毒患者在常规洗胃、应用阿托品及解磷定的救治时,加入药用炭片与不加入药用炭片的临床效果。结果药用炭片组的阿托品用量(327±186)mg较未用炭片组(525±364)mg明显减少,而胆碱酯酶活力的恢复时间(86±27)h较未用炭片组(102±31)h明显缩短,差异有统计学意义(P<0.05或P<0.01);药用炭片组的治愈率(89.47%)较未用炭片组明显提高,病死率(10.26%)较未用炭片组(29.63%)明显降低,差异均有统计学意义(P<0.05)。结论治疗中加入药用炭片可明显减少阿托品用量,缩短胆碱酯酶活力恢复时间,提高有机磷中毒的治愈率。
Objective To observe the effect of medicinal charcoal injection of gastric tube and retention enema on organophosphate poisoning. Methods A retrospective analysis of 66 cases of organophosphate poisoning in patients with routine gastric lavage, the application of atropine and Phosphodpirin treatment, the medicinal charcoal with or without the use of medicinal charcoal clinical effect. Results The amount of atropine (327 ± 186) mg in the medicinal charcoal tablets group was significantly lower than that of the untreated carbon tablets group (525 ± 364 mg), while the recovery time of the cholinesterase activity (86 ± 27 h) (102 ± 31) h was significantly shorter, the difference was statistically significant (P <0.05 or P <0.01); the cure rate of the medicinal carbon tablets group (89.47%) was significantly higher than the non-carbon tablets group, the mortality rate %) Was significantly lower than the unused carbon tablets group (29.63%), the differences were statistically significant (P <0.05). Conclusion The addition of medicinal carbon tablets can significantly reduce the amount of atropine, shorten the recovery time of cholinesterase activity and improve the cure rate of organophosphate poisoning.