目的建立皮肤放射性损伤的动物模型。方法采用直线加速器发射的β射线,对不同照射剂量组造成的皮肤损伤进行对比,通过病理切片以及电镜的观察,研究皮肤放射性损伤的造模方法。结果 30 Gy剂量组光镜下有明显改变并有凋亡小体形成;电镜结果显示细胞核固缩明显,细胞濒临死亡。结论采用直线加速器发射的β射线(照射剂量30 Gy),能造成大鼠皮肤辐射损伤的模型,方法简单可行,效果可靠。 Objective To establish an animal model of skin radioactive injury. Methods The β ray emitted by a linear accelerator was used to compare the skin lesions caused by different irradiation dose groups. Pathological sections and electron microscopy were used to study the methods of making radioactive lesions of the skin. Results The dose of 30 Gy significantly changed under light microscope and the formation of apoptotic bodies. The electron microscopy showed that the nuclei were obviously condensed and the cells were dying. Conclusion The β ray emitted by a linear accelerator (radiation dose of 30 Gy) can cause radiation damage in rat skin. The method is simple and feasible and reliable.