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目的探讨替罗非班在急性下肢动脉栓塞治疗的应用效果。方法总结和分析2005年1月至2008年9月收治的64例急性下肢动脉栓塞患者的临床资料:均采用导管介入方法吸取血栓,介入配合替罗非班治疗33例,对照组31例,观察两组治疗效果的差异。结果64例下肢动脉急性栓塞患者均采用介入方法成功去除大部分栓子,开通主干动脉。替罗非班治疗组术后再次血运重建率、截肢(趾)率、病死率均低于非替罗非班组,两组差异有统计学意义,且无严重出血发生。结论替罗非班配合介入治疗急性下肢动脉栓塞疗效好,且用药安全性较好。
Objective To investigate the effect of tirofiban in the treatment of acute lower extremity arterial embolization. Methods The clinical data of 64 patients with acute lower extremity arterial embolism admitted from January 2005 to September 2008 were summarized and analyzed. Thrombus was obtained by catheterization, 33 cases were treated with tirofiban and 31 cases were as control. The difference between the two groups of treatment effect. Results 64 cases of acute lower extremity arterial embolization patients were successfully involved in the removal of most of the emboli, the opening of the main artery. The rates of revascularization, amputation (amputation) and mortality in the tirofiban group were lower than those in the non-tirofiban group after treatment. The difference between the two groups was statistically significant and no severe bleeding occurred. Conclusion Tirofiban combined with interventional treatment of acute lower extremity arterial embolization has good curative effect and the medication is safe.