靶向毒素,亦称为免疫毒素或细胞毒素,是一种肿瘤细胞表面特异性抗原或受体相结合的细胞分子。如与EG-FR、IL-13受体等相结合的细胞分子,其毒素成份可杀死肿瘤细胞。目前研究的毒素多为以白喉毒素、假单胞杆菌外毒素等为母基合成的毒素。双重特异性靶向毒素能同时靶向肿瘤细胞和/或其新生血管上的两个过表达受体的毒素,如DTAT13靶向uPAR和IL-13受体,DTATEGF靶向EGFR和uPAR,其较单一靶向毒素具有更高的特异性和更强的毒性,同时免疫源性亦大为降低。寻找特异性的肿瘤细胞表面标志物、降低毒素的免疫源性及研究实体肿瘤毒素的投递方式是靶向毒素治疗脑肿瘤的研究方向。 Targeted toxins, also known as immunotoxins or cytotoxins, are tumor cell surface-specific antigens or receptor-bound cellular molecules. Such as EG-FR, IL-13 receptor and the combination of the cell molecules, the toxin components can kill tumor cells. At present, most of the toxins are toxins synthesized from diphtheria toxin, Pseudomonas exotoxin and the like. Dual-specific targeting toxins can target both toxins over-expressing receptors on tumor cells and / or their neovasculature, such as DTAT13 targeting uPAR and IL-13 receptors, DTATEGF targeting EGFR and uPAR, Single target toxins have higher specificity and more toxicity, while immunogenicity is also greatly reduced. Looking for specific tumor cell surface markers to reduce the immunogenicity of toxins and to study the delivery of solid tumor toxins is the research direction of targeting toxins in the treatment of brain tumors.