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40例慢性萎缩性胃炎(CAG)患者随访5～11年,每例随访行活检3～8次,取每例首、中、末三次活检标本观察,除HE染色切片外,并作HID/AB(PH2.5)/PAS及PB/KOH/PAS两种粘液染色进行观察。前后三次对比结果:约半数不变,1/3~+加重,少数减轻。1例原有轻度不典型增生(ATP)病变者消失;2例随访后发生轻、重度ATP,其后1例发生癌变(2.6%)。本组资料表明:1.ATP病变是可逆的,CAG患者在长期随访中仅少数(7.7%)发生ATP病变;2.CAG为癌前疾病,只有伴重度ATP病变者才有发生癌的可能,且进展较慢;3.CAG病变与粘液分泌性质尚未见密切关系。
40 patients with chronic atrophic gastritis (CAG) were followed up for 5 to 11 years. Each patient was followed up for 3 to 8 times. The biopsy specimens of the first, middle, and last time were taken for each case. HID/AB was performed in addition to HE staining. (PH2.5) / PAS and PB / KOH / PAS two kinds of mucus staining observed. Comparison results before and after three times: about half unchanged, 1/3~+ aggravated, a few eased. One case of the original mild atypical hyperplasia (ATP) lesions disappeared; 2 cases were followed by mild and severe ATP, followed by 1 case of cancer (2.6%). This group of data showed that: 1. ATP lesions are reversible, CAG patients in a long-term follow-up only a few (7.7%) ATP lesions; 2. CAG precancerous lesions, only with severe ATP lesions may have cancer, And the progress is slow; 3.CAG lesions and mucus secretion has not yet been closely related.