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目的探讨不同精液质量的ICSI(卵泡浆内单精子显微注射)周期中卵子受精与胚胎发育潜能间的差异。方法采用回顾性资料分析的方法,比较了中心71例ICSI治疗周期。女方正常者根据精液质量分为严重少弱畸精子组(A组,n=31)与非严重少弱畸精子组(B组,n=24),非严重少弱畸精子组合并女方异常为C组(n=16)。从形态学方面评估三组中受精率、(two pronuclear,2PN)率、异常受精率、未受精率、卵裂率、可用胚胎率、优质胚胎率、不可用胚胎率等实验室指标间的差异。结果三组在卵子受精率、2PN率、异常受精率、未受精率、卵裂率、可用胚率、优质胚胎率和不可用胚胎率等方面比较,差异均无统计学意义(P>0.05)。但B组的受精率(72.29±23.12)低于C组(85.49±18.59),两组差异有统计学意义(P<0.05);未受精率B组(22.81±22.83)高于C组(14.51±18.59),两组差异有统计学意义(P<0.05)。结论从形态学上看,ICSI前的精液质量对卵子受精及胚胎发育没有明显影响。
Objective To explore the differences between fertilization and embryonic development potential of ICSI (follicle sperm intracytoplasmic sperm injection) with different semen quality. Methods Retrospective data analysis method was used to compare the center 71 ICSI treatment cycles. According to the quality of semen, the normal women were divided into severe oligozoospermia group (group A, n = 31) and non-severe oligozoospermia group (group B, n = 24) Group C (n = 16). Morphological evaluation of three groups of fertilization rate (two pronuclear, 2PN) rate, abnormal fertilization rate, unfertilized, cleavage rate, available embryo rate, high-quality embryo rate, the rate of unusable embryo and other laboratory indicators differences . Results There was no significant difference in fertilization rate, 2PN rate, abnormal fertilization rate, unfertilized rate, cleavage rate, available embryo rate, excellent embryo rate and unusable embryo rate between the three groups (P> 0.05) . However, the fertilization rate in group B (72.29 ± 23.12) was lower than that in group C (85.49 ± 18.59), with significant difference between the two groups (P <0.05). The fertilization rate in group B (22.81 ± 22.83) was higher than that in group C ± 18.59), the difference between the two groups was statistically significant (P <0.05). Conclusion Morphologically, semen quality before ICSI had no significant effect on fertilization and embryo development.