论文部分内容阅读
心房颤动(简称房颤)患者脑卒中危险增加,主要是由于来自左心耳(LAA)的血栓栓塞。作者最近报告房颤时,内皮功能不良限于左房(LA)及LAA,表现为NO生成减少,PAI-I生成增加,于是提出下述假说:房颤时观察到的LAA NO水平降低,同时可能O2生成增加。方法与结果猪快速心房起搏造成房颤1周
Patients with atrial fibrillation (AF) have an increased risk of stroke, primarily due to thromboembolism from the left atrial appendage (LAA). The authors recently reported that endothelial dysfunction was limited to left atrium (LA) and LAA during atrial fibrillation, with a reduction in NO production and increased PAI-I production. The authors then proposed the hypothesis that the observed LAA NO level decreases during atrial fibrillation O2 generation increases. Methods and Results Pig rapid atrial pacing caused atrial fibrillation for 1 week