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人成熟单核细胞为组织巨噬细胞和树突状细胞(DC)的前体细胞,具有异质性,不同亚群表型特征和功能存在差异。单核细胞表达大量的黏附分子和趋化因子受体,在抗肿瘤、抗微生物感染以及淋巴细胞激活等方面都发挥关键作用。丙型肝炎病毒(HCV)感染时,病毒蛋白可通过影响单核细胞重要免疫调节细胞因子的分泌以及后续的DC成熟抑制和Th1细胞应答的破坏和失能,干扰机体抗病毒特异性免疫应答以建立持续性感染,而阻断上述过程关键因子也成为治疗HCV感染新的免疫策略。本文主要综述HCV感染后单核细胞介导的免疫效应的功能特点及机制的相关研究进展。
Human mature monocytes are precursors of tissue macrophages and dendritic cells (DCs) that are heterogeneous and differ in their phenotypic characteristics and functions. Monocytes express large numbers of adhesion molecules and chemokine receptors that play key roles in anti-tumor, anti-microbial infections, and lymphocyte activation. In the case of hepatitis C virus (HCV) infection, viral proteins can interfere with the antiviral-specific immune response in the body by affecting the secretion of important immunoregulatory cytokines in monocytes and subsequent destruction of DC maturation and the destruction and disability of Th1 cell responses Establish a persistent infection, and blocking the key factors of the process has become a new immunization strategy for the treatment of HCV infection. This review summarizes the functional characteristics and mechanisms of monocyte-mediated immune response after HCV infection.