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目的探讨自由基与肝脏疾病的关系。方法应用透射比浊法测定７６例不同类型的肝病患者血清中过氧化脂质含量和超氧化物歧化酶活性。将检测结果进行统计学分析和各组间进行比较。结果急性肝炎、慢活肝、肝硬化和肝癌患者过氧化脂质含量明显高于对照组（Ｐ＜００１）；超氧化物歧化酶活性均低于对照组（Ｐ＜００５）；尤其是肝癌患者超氧化物歧化酶活性降低更为显著（Ｐ＜００１）。结论肝病患者血清中过氧化脂质含量和超氧化物歧化酶活性的测定，对病情轻重的判断及预后有重要的临床意义。
Objective To investigate the relationship between free radicals and liver diseases. Methods The serum lipid peroxidation and superoxide dismutase activity in 76 patients with different types of liver disease were measured by transmission nephelometry. The test results were statistically analyzed and compared between groups. Results The levels of lipid peroxidation in patients with acute hepatitis, chronic liver disease, cirrhosis and liver cancer were significantly higher than those in the control group (P <001). The activity of superoxide dismutase was lower than that in the control group (P <005). Especially, the decrease of superoxide dismutase activity was more significant in patients with liver cancer (P <001). Conclusion Determination of serum lipid peroxidation and superoxide dismutase activity in patients with liver disease has important clinical significance in the judgment and prognosis of the severity of illness.