近来,我们用大剂量甲氨蝶呤联合长春新碱治疗骨恶性肿瘤4例,效果满意.1 资料与方法1.1 一般资料 本组4例,男、女各2例,年龄41岁～65岁,平均52岁,坐骨软骨肉瘤2例,股骨上端恶性纤维组织细胞瘤、股骨下端骨肉瘤各1例.(术前及术后1个月各化疗1疗程,每疗程为3d).1.2 用药方法 第1天:补液、水化,每日补液>3000ml.用5%碳酸氢钠250ml静脉滴注,qd×3 Recently, we used high-dose methotrexate combined with vincristine to treat 4 cases of bone malignancy with satisfactory results. 1 Materials and Methods 1.1 General Information 4 patients in this group, 2 males and 2 females, aged 41 to 65 years old, Average 52 years old, 2 cases of ischorochondrial chondrosarcoma, 1 case of malignant fibrous histocytoma on the upper femur, 1 case of osteosarcoma on the lower part of the femur (1 course of chemotherapy before and 1 month after surgery, each course of treatment was 3 days). 1.2 Method of administration 1 day: rehydration, hydration, daily rehydration> 3000 ml. IV infusion with 5% sodium bicarbonate 250 ml, qd×3