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目的观察和分析慢性阻塞性肺疾病急性期(AECOPD)患者的凝血功能的变化。方法选取100例AECOPD患者作为病例组,选取100例健康志愿者作为对照组,对两组研究对象的凝血酶原时间(PT)、活化部分凝血活酶时间(aPTT)、纤维蛋白原(Fbg)、凝血酶时间(TT)、D二聚体(D-D)及动脉血气指标、血常规指标、呼吸功能指标进行观察和比较。结果病例组患者的动脉血PH值、动脉血PaO_2、PLT、FEV1、FEV1%、FEV1/FVC水平均显著低于对照组,而动脉血PaCO_2、RBC、WBC水平均显著高于对照组,两组之间的差异均有统计学意义(P<0.05);病例组患者的Fbg水平显著高于对照组,而aPTT水平显著低于对照组,差异均有统计学意义(P<0.05);病例组患者的D-D水平显著高于对照组,差异均有统计学意义(P<0.05)。结论 AECOPD患者体内存在高凝状态和纤溶功能亢进,及时的监测与有效的干预可提高治疗效果、改善预后。
Objective To observe and analyze the changes of coagulation function in patients with acute obstructive pulmonary disease (AECOPD). Methods A total of 100 patients with AECOPD were enrolled in this study. 100 healthy volunteers were selected as control group. Prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen (Fbg) , Thrombin time (TT), D dimer (DD), arterial blood gas index, blood routine index and respiratory function index were observed and compared. Results The arterial blood PH, PAO 2, PLT, FEV 1, FEV 1% and FEV 1 / FVC were all significantly lower in patients than those in control group, while the PaCO 2, RBC and WBC in arterial blood were significantly higher than those in control group (P <0.05). The Fbg level of patients in the case group was significantly higher than that of the control group, while the level of aPTT was significantly lower than that of the control group (P <0.05). The case group Patients with DD levels were significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusion AECOPD patients with hypercoagulable state and hyperfibrinolysis in vivo, timely monitoring and effective intervention can improve the therapeutic effect and improve the prognosis.