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作为P40家族中研究最为广泛的细胞因子,白细胞介素-12(Interleukin-12)其最显著的特点是有助于Th1细胞分化,参与由Th1细胞所介导的免疫性疾病。而白细胞介素-23(Interleukin-23)与Th17细胞增殖有关,最新发现Th17介导的免疫反应在实验性变态反应性脑脊髓炎(EAE)和多发性硬化症(MS)疾病方面发挥重要作用,并且其分化途径的提出对传统的Th1/Th2细胞免疫也带来了新的挑战[1]。该家族的另外两个成员P40单体和P40同源二聚体也参与免疫调控,实验证明P40分子不仅在细胞内感染及炎症过程中起着重要的调节作用,而且与银屑病、多发性硬化症、Crohn’s病等多种自身免疫性临床疾病的发病密切相关。
As the most widely studied cytokine in the P40 family, Interleukin-12 is most notable for its role in Th1 cell differentiation and its involvement in Th1-mediated immune diseases. Interleukin-23 is associated with the proliferation of Th17 cells. The recent finding that Th17-mediated immune responses play an important role in experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS) , And the way of its differentiation put forward new challenges to traditional Th1 / Th2 cell immunity [1]. The other two members of the family, P40 and P40 homodimers, are also involved in immune regulation. Experiments show that P40 plays an important regulatory role not only in intracellular infection and inflammation, but also with psoriasis, multiple Sclerosis, Crohn’s disease and other autoimmune clinical diseases are closely related.