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目的：研究药物透皮吸收行为的药剂学规律。方法：用改良的Ｆｉｃｋ’ｓ扩散装置，测定１００种药物在小鼠皮肤的透皮速率，并与含２％和５％促渗剂月桂氮酮进行比较，通过计算药物的累积渗透量（Ｑ），稳态透皮速率（Ｊ）和渗透系数（Ｋｐ），以探讨药物透皮吸收的药剂学规律。结果与分析：研究分析①药物理化性质与药物透皮行为的药剂学规律。②预测药物透皮吸收的数学（或经验）公式。③考察不同浓度的月桂氮酮对药物透皮渗透性的影响及对数学方程式的影响。
Objective: To study the pharmacology of drug transdermal absorption. METHODS: The transdermal rate of 100 drugs in mouse skin was measured using a modified Fick’s diffusion device and compared with laurolinone with 2% and 5% penetration enhancers by calculating the cumulative drug permeation ( Q), steady-state transdermal rate (J) and osmotic coefficient (Kp) were calculated to investigate the pharmacology of drug transdermal absorption. Results and Analysis: Study and analysis ①Physical and Chemical Properties and Pharmacological Rules of Drug Transdermal Behavior. ② predict the transdermal drug absorption mathematical (or experience) formula. (3) Investigate the effect of different concentrations of azaseride on transdermal permeability of drug and its influence on mathematical equation.