评述了高效液相色谱中纤维素衍生物手性固定相直接拆分对映体的进展。介绍了纤维素衍生物的主要类型、纤维素衍生物作手性固定相三种不同方式的特点以及新的纤维素衍生物手性固定相应用。并结合色谱、NMR和分子模型设计和理论计算等方法讨论了纤维素衍生物手性固定相的拆分机理 The progress of direct resolution of enantiomers of cellulose derivatives chiral stationary phase in high performance liquid chromatography (HPLC) was reviewed. The main types of cellulose derivatives, the characteristics of three different ways of using cellulose derivatives as chiral stationary phases and the application of new cellulose derivatives as chiral stationary phases are introduced. Combining with the methods of chromatography, NMR and molecular model design and theoretical calculation, the mechanism of the splitting of chiral stationary phase of cellulose derivatives