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目的:建立复方丹参注射液的含量测定方法,考察复方丹参注射液与4种常用输液的配伍稳定性。方法:采用高效液相色谱法测定复方丹参注射液的含量,同时考察其外观、颜色、pH值、不溶性微粒的变化。结果:室温下放置6h,复方丹参注射液与5%葡萄糖注射液配伍,输液的含量、pH值、外观、不溶性微粒均无明显变化;与10%葡萄糖注射液、0.9%氯化钠注射液和葡萄糖氯化钠注射液配伍,输液的含量、外观、pH值无明显变化,但是不溶性微粒显著增加。结论:复方丹参注射液可与5%葡萄糖注射液配伍应用,不能与10%葡萄糖注射液、0.9%氯化钠注射液和葡萄糖氯化钠注射液配伍应用。
OBJECTIVE: To establish a method for the determination of Compound Salvia Miltiorrhiza injections and investigate the compatibility of Compound Salvia Miltiorrhiza injections with four common infusion solutions. Methods: The content of Fufang Danshen injection was determined by high performance liquid chromatography (HPLC), and the changes of its appearance, color, pH and insoluble particles were also investigated. Results: After 6h at room temperature, compound Danshen injection and 5% dextrose injection had no significant change in the content, pH, appearance and insoluble particles of the infusion solution. Compared with 10% glucose injection, 0.9% sodium chloride injection and Glucose and sodium chloride injection compatibility, infusion content, appearance, pH no significant change, but significant increase in insoluble particles. Conclusion: Salvia miltiorrhiza injection can be used in combination with 5% glucose injection and can not be used with 10% glucose injection, 0.9% sodium chloride injection and glucose and sodium chloride injection.