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非甾体类消炎药(NSAID)由于其多种因素而抑制胃溃疡的愈合,如减少上皮细胞和成纤维细胞增生及影响溃疡边缘肉芽组织的血管生成。业已发现人类胃粘膜中有碱性成纤维细胞生长因子(bFGF),并有证据表明其在溃疡愈合中起重要作用。与无溃疡患者相比,GU患者体内bFGF明显下降(平均23倍)。本研究旨在观察应用外源性bFGF(TGP-580人类重组bFGF衍生物)治疗NSAID相关溃疡的安全性和有效性。 方法:选择因临床需要持续应用NSAID治疗的患者,胃镜证实有一个或更多胃溃疡
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit gastric ulcer healing due to a variety of factors, such as reducing proliferation of epithelial cells and fibroblasts and affecting angiogenesis at the marginal granulation tissue of ulcers. It has been found that human gastric mucosa has basic fibroblast growth factor (bFGF) and there is evidence that it plays an important role in ulcer healing. In patients with GU, there was a significant reduction in bFGF (mean, 23-fold) in patients with ulceration. This study aimed to observe the safety and efficacy of exogenous bFGF (TGP-580 human recombinant bFGF derivative) in the treatment of NSAID-related ulcers. Methods: Patients who were selected for continued NSAID treatment due to clinical need were enrolled in this study. Gastroscopy confirmed one or more gastric ulcers