随着机械通气在儿科的广泛应用,高浓度氧(简称高氧)肺损伤逐渐引起人们的重视,患儿持续吸入高氧短期内引起高氧急性肺损伤(hyperoxic acute lung injury,HALI),同时也是罹患支气管肺发育不良(bronchopulmonary dysplasis,BPD)的重要的病理基础。Src抑制的蛋白激酶C的底物(srcsuppressed C kinase substrate,SSeCKS)蛋白是一种新发现的细胞支架蛋白,它不仅参与细胞运动、调节细胞周期;通 With the widespread use of mechanical ventilation in pediatrics, high concentrations of oxygen (referred to as hyperoxia) lung injury gradually attracted people’s attention, children with persistent inhalation of hyperoxia in a short period of time caused hyperoxic acute lung injury (HALI) It is also an important pathological basis for the development of bronchopulmonary dysplasia (BPD). The Src-suppressed srccrppressed C-kinase substrate (SSeCKS) is a newly discovered cell scaffold protein that not only participates in cell motility and regulates cell cycle;