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1972年Maroko等报道,极化液(葡萄糖—胰岛素一氯化钾溶液)可起到保护缺血心肌组织,缩小或限制动物(狗)实验性心肌梗塞范围的作用。继之,Opie等于1975年报道了极化液对狒狒实验性心肌梗塞的影响,认为极化液能改善心肌能量代谢,提高缺血区ATP(三磷酸腺苷),糖原及磷酸盐水平。1976年起,Rogers及其同事开始将极化液用于急性心肌梗塞病人。现不少医疗单位
In 1972, Maroko et al. Reported that the polar fluid (glucose-insulin potassium chloride solution) can protect ischemic myocardium and reduce or limit the range of experimental myocardial infarction in dogs. Following that, Opie et al. Reported in 1975 that the effect of polarized fluid on experimental myocardial infarction in baboons suggests that the polar fluid can improve myocardial energy metabolism and increase ATP (ATP), glycogen and phosphate levels in the ischemic area. Since 1976, Rogers and colleagues began using the pooled solution in patients with acute myocardial infarction. Now many medical units