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目的 探讨化疗联合放疗治疗晚期非小细胞肺癌的疗效。方法 选择 5 2例晚期非小细胞肺癌 ,分两组。单放组采用常规分割 ,总剂量为 6 0～ 6 8GY/ 6～ 7周 ;综合组采用放疗加化疗 ,化疗采用EP方案 ,在放疗前、同时或放疗后进行 ,共 3～ 4周期。结果 单放组总缓解率 4 5 5 % ,中位生存 11个月 ,1、2、3年生存率为 4 5 5 %、18 2 %、4 5 %。综合组总缓解率为 6 6 7% ,中位生存 2 0个月 ,1、2、3年生存率为 73 3%、2 6 7%、16 6 %。综合组优于单放组 (P <0 0 5 )。综合组不良反应大于单放组 ,主要表现为骨髓抑制 ,但病人均能耐受。结论 EP方案联合放疗治疗晚期非小细胞肺癌疗效优于单放组 ,能够提高 1、2、3年生存率。
Objective To investigate the efficacy of chemotherapy combined with radiotherapy in the treatment of advanced non-small cell lung cancer. Methods 52 cases of advanced non-small cell lung cancer were selected and divided into two groups. The patients in the radiotherapy group were divided into two groups according to the conventional method. The total dose was 60 ~ 68 Gy / 6 ~ 7 weeks. The radiotherapy combined with radiotherapy and chemotherapy were used in the radiotherapy group. The radiotherapy was performed before, simultaneously with or after radiotherapy. Results The total remission rate was 45.5%. The median survival time was 11 months. The 1, 2, 3 year survival rates were 45.5%, 18.2% and 45%, respectively. The overall response rate was 66.7% in the combined group and 20 months in the median. The 1, 2, 3-year survival rates were 73.3%, 26.7% and 16.6% respectively. The combined group was better than the single group (P <0 05). Adverse reactions in the combined group were greater than those in the single group, which mainly manifested as myelosuppression, but the patients were able to tolerate. Conclusion The EP regimen combined with radiotherapy is superior to radiotherapy alone in the treatment of advanced non-small cell lung cancer and can improve the 1, 2, 3 year survival rates.