子痫前期是严重危害母婴健康的产科常见病,是导致孕产妇和围生儿发病率和死亡率升高的主要原因之一。其病因至今还不十分明确。烟酰胺腺嘌呤二核苷酸磷酸(nicotinamide-adenine dinucleotide phosphate,NADPH)氧化酶是人体内广泛存在的一种氧化酶,其催化产生的活性氧簇(reactive oxygen spieces,ROS)在宿主防御、生物合成、炎症反应、血管的生理和病理中起重要作用,参与高血压、动脉粥样硬化、心肌梗死、糖尿病性微血管病、子痫前期等的发病过程。就其与子痫前期发病关系的研究进展作综述。 Preeclampsia is a common obstetric disease that seriously affects the health of mothers and infants and is one of the major causes of morbidity and mortality in pregnant women and perinatal infants. The cause is still not very clear. Nicotinamide adenine dinucleotide phosphate (nicotinamide-adenine dinucleotide phosphate, NADPH) oxidase is widely present in the body of an oxidase, which catalyzed the production of reactive oxygen species (reactive oxygen spieces, ROS) in the host defense, biological Synthesis, inflammation, vascular physiology and pathology play an important role in hypertension, atherosclerosis, myocardial infarction, diabetic microangiopathy, preeclampsia and other pathogenesis. The research progress of the relationship with preeclampsia is reviewed.