肿瘤疾病的药物治疗一直是医学界的困扰,因为机体的多个受体都与发病有关,并且关系到病情的发展,此外信号通路也是相关因素。经过临床长期病理研究和药理分析,多靶点制剂被专家、学者认可,其较单靶点制剂具有使用优势,可以通过干扰肿瘤信号转导从而防治疾病。该文将把此类制剂按照化学结构划分,概述多靶点氨酸激酶抑制剂的新进展。 Medical treatment of oncological diseases has long been plagued by the medical community as multiple receptors on the body are associated with the onset and progression of the disease and in addition the signaling pathways are also relevant. After clinical long-term pathological studies and pharmacological analysis, multi-target preparation is recognized by experts and scholars, which has more advantages than single-target preparation and can prevent and treat diseases by interfering with tumor signal transduction. This article will be based on the chemical structure of such preparations, outlined the new progress of multi-target kinases inhibitors.