目的 :比较用摇摆式、挤压式和快速搅拌制粒方法制备的结代停冲剂颗粒的形貌、吸湿及溶解性能 ,从制粒工艺的差异 ,讨论各种因素的影响。方法 :用光学显微和测吸湿百分率及溶解速率来研究各种颗粒的形貌及吸湿和溶解速率。结果 :溶解速率 ,挤压制粒 <快速搅拌制粒 <摇摆制粒 ;吸湿百分率 ,快速搅拌制粒 <挤压制粒 <摇摆制粒。结论 :快速搅拌制粒的颗粒稳定性较好 ,适应结代停冲剂的制备 Objectives : To compare the morphology, moisture absorption and dissolution properties of the granules produced by the oscillating, squeezing and rapid agitation granulation methods, and to discuss the influence of various factors from the differences in the granulation process. Methods : Optical microscopy and hygroscopicity and dissolution rates were used to study the morphology and hygroscopicity and dissolution rates of various particles. Results : Dissolution rate, extrusion granulation