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为了探讨输尿管癌临床病理因素对预后的影响,回顾性分析1995-01-2008-12接受手术治疗的原发输尿管癌51例患者的临床资料。在51例输尿管癌患者中,年龄(P=0.000)、临床分期(P=0.004)、组织学分级(P=0.000)及手术方式(P=0.048)与输尿管癌手术预后显著相关;性别(P=0.655)、肿瘤部位(P=0.245)及病理分级(P=0.092)与输尿管癌手术预后无关。临床分期中,浅表性输尿管癌(Ta～T1)10例(19.6%),浸润性输尿管癌(T2～T4)41例(80.4%),Kaplan-Meier法分析显示,浸润性输尿管癌生存率明显低于表浅输尿管癌,P=0.002。多因素Cox回归模型生存分析结果表明,临床分期(P=0.021)、组织学分级(P=0.001)、病理分级(P=0.048)及手术方式(P=0.039)是影响手术预后最显著的独立因素。初步研究结果提示,输尿管癌临床病理分级及手术方式与患者的生存相关,可作为患者的独立预后因素。
In order to investigate the clinicopathological factors of ureteral carcinoma on prognosis, the clinical data of 51 patients with primary ureteral carcinoma undergoing surgery from January 1995 to December 2008 were retrospectively analyzed. In 51 patients with ureteral carcinoma, the age (P = 0.000), clinical stage (P = 0.004), histological grade (P = 0.000) and operation method (P = 0.048) were significantly correlated with the prognosis of ureteral cancer; = 0.655), tumor location (P = 0.245) and pathological grade (P = 0.092) had no correlation with the prognosis of ureteral cancer. In the clinical stage, 10 cases (19.6%) of superficial ureteral carcinoma (Ta ~ T1) and 41 (80.4%) of invasive ureteral carcinoma (T2 ~ T4) were analyzed by Kaplan-Meier method. The survival rate of invasive ureteral carcinoma Obviously lower than superficial ureteral carcinoma, P = 0.002. Multivariate Cox regression model survival analysis showed that clinical stage (P = 0.021), histological grade (P = 0.001), pathological grade (P = 0.048) and surgical method (P = 0.039) were the most significant independent prognostic factors factor. Preliminary results suggest that the clinicopathological grade of ureteral carcinoma and surgical methods related to the survival of patients, can be used as an independent prognostic factor in patients.