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目的：：探讨透明质酸钠和几丁糖分别用于甲状腺术后粘连的治疗效果。方法：甲状腺手术患者84例根据入院时间分为甲、乙两组各42例,为防止术后粘连,甲组采用透明质酸钠3~6 ml均匀涂抹于创面、颈前肌群深面和颈阔肌深面,乙组采用3~6 ml均匀涂抹于上述位置。术后5~7 d拆线出院,3个月后评估预防粘连效果,比较两组临床疗效及不良反应发生情况。结果：甲组粘连率为14.3%(6/42),略高于乙组7.1%(3/42),但差异无统计学意义(P>0.05)；两组患者均无渗血和过敏等不良反应,仅甲组出现2例(4.8%)轻微感染者,两组不良反应发生率差异无统计学意义(P>0.05)。结论：透明质酸钠和几丁糖均有预防甲状腺术后粘连的效果,两者预防有效率和不良反应基本相当。“,”Objective:To investigate and compare the effect of sodium hyaluronate and chitosan in the prevention of thyroid post-operative adhesion. Methods:Totally 84 patients with thyroid operation in our hospital from August 2012 to August 2013 were select-ed, and according to the admission time, the patients were respectively divided into group A and B with 42 cases each. In order to pre-vent postoperative adhesion, group A was treated with sodium hyaluronate, and group B was treated with chitosan. The clinical curative effect of the two groups was compared. Results: The adhesion rate in group A was 14. 3%(6/42), which was higher than that in group B (3/42 7. 1%), while the difference was not statistically significant (P>0. 05). All the patients showed no bleeding, aller-gies and other adverse reactions, only in group A, 2 mild infection (4. 8%) occurred. The adverse reactions in the two groups were without significant difference (P>0.05). Conclusion: Sodium hyaluronate and chitosan both have the preventive effect on thyroid postoperative adhesion with similar efficiency and adverse reactions.