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目的:研究卡培他滨联合草酸铂治疗晚期结直肠癌的近期疗效和毒副反应。方法:希罗达1 250 mg/m2,每日2次口服,第1天~ 14天;草酸铂(奥沙利铂)130 mg/m2 溶入5 % 葡萄糖注射液250 mL中静脉滴注2 h,第1天,21天为1周期。至少连用2个周期后评价疗效。结果:37例患者CR3例(8.1 %)、PR16例(43.2 %)、SD13例(35.1 %)、PD5例(13.5 %),有效率51.4 %。主要毒副反应为恶心、呕吐、腹泻、血白细胞减少、手足综合征、末梢神经异常、口腔黏膜炎。结论:卡培他滨联合草酸铂化疗晚期结直肠癌的疗效确切,并可提高患者的生活质量,毒副反应小,患者可以耐受。
Objective: To study the curative effect and toxicity of capecitabine combined with oxaliplatin in the treatment of advanced colorectal cancer. Methods: Xeloda 1 250 mg / m2 orally twice daily for 1 day to 14 days; oxaliplatin (oxaliplatin) 130 mg / m2 dissolved in 5% dextrose injection 250 mL intravenously 2 h, day 1, 21 days for a cycle. Evaluate efficacy after at least 2 cycles. Results: CR3 (8.1%), PR16 (43.2%), SD13 (35.1%) and PD5 (13.5%) were effective in 37 patients. The effective rate was 51.4%. The main side effects of nausea, vomiting, diarrhea, leukopenia, hand-foot syndrome, peripheral nerve abnormalities, oral mucositis. Conclusion: Capecitabine combined with oxaliplatin chemotherapy for advanced colorectal cancer is effective and can improve the quality of life of patients with less toxic side effects and patients can tolerate.