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目的 探讨溶栓治疗对纤维系统的影响以及各指标与临床疗效的关系。方法 对 ６９ 例病后 ２４ｈ 内就治的急性脑梗塞病人随机分 ４ 组，在治疗前及治疗后 ２ｈ、２４ｈ、７～１０ｄ 进行组织型纤溶酶原激活物（ｔ Ｐ Ａ）、纤溶酶原激活物抑制物（ Ｐ Ａ Ｉ）、纤溶酶原（ Ｐ Ｌ Ｇ）、 Ｄ二聚体（ Ｄ Ｄ）检测。结果 对照组ｔ Ｐ Ａ、 Ｐ Ａ Ｉ、 Ｐ Ｌ Ｇ、 Ｄ Ｄ 在治疗前及治疗后各时期无变化，溶栓治疗组于治疗后 ２ｈ ｔ Ｐ Ａ 及 Ｄ Ｄ 明显升高， Ｐ Ａ Ｉ、 Ｐ Ｌ Ｇ 下降。溶栓治疗并发出血的病例，于治疗后 ２４ｈ Ｐ Ａ Ｉ仍明显降低。结论 溶栓治疗病例存在超早期纤溶激活，凝血障碍是溶栓治疗并发出血的重要机制。
Objective To investigate the influence of thrombolytic therapy on fibrosis and the relationship between each index and clinical efficacy. Methods Sixty-nine patients with acute cerebral infarction who were treated within 24 hours after treatment were randomly divided into 4 groups. Tissue plasminogen activator (t P A), fibrinolysis Enzyme inhibitor (P A I), plasminogen (P L G), D dimer (D D) detection. Results There were no changes in t P A, P A I, P L G, and D D in the control group before and after treatment. The levels of P A and D D were significantly increased at 2 h after treatment in the thrombolytic group, P A I, P L G decreased. Thrombolytic therapy with bleeding cases, 24h after treatment, P A I was significantly reduced. Conclusion Thrombolytic therapy exists in patients with early early fibrinolytic activation, coagulation disorders is an important mechanism of thrombolytic therapy and bleeding.