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目的:探讨5-氟尿嘧啶联合更生霉素治疗侵蚀性葡萄胎的临床效果。方法:选取我院2015年1月—2016月1月年期间收取的32例侵蚀性葡萄胎患者,给予以上所有患者5-氟尿嘧啶联合更生霉素治疗,对治疗后的效果和预后进行详细的分析。结果:所有患者在治疗前的血清中的绒毛激素水平为(942.3±25.65)U/L,而治疗的水平明显的下降至(58.35±7.2)U/L;所有患者中显效19例,显效率为59.37%,有效9例,有效率为28.13%,无效4例,无效率为12.50%,治疗总有效28例(87.50%)。结论:侵蚀性葡萄胎临床应用5-氟尿嘧啶联合更生霉素的治疗效果明显,对该类患者预后的意义重大,因此该种治疗方法值得临床推广及应用。
Objective: To investigate the clinical effect of 5-fluorouracil and dactinomycin in the treatment of invasive hydatidiform mole. Methods: 32 patients with invasive hydatidiform mole collected from January 2015 to January 2016 in our hospital were treated with 5-fluorouracil combined with dactinomycin, and the effects and prognosis after treatment were analyzed in detail . Results: The level of villus hormone in all the patients before treatment was (942.3 ± 25.65) U / L, while the level of treatment was significantly decreased to (58.35 ± 7.2) U / L. In all patients, 19 cases were markedly effective, 59.37%, effective in 9 cases, effective rate was 28.13%, ineffective in 4 cases, inefficiency rate of 12.50%, and total effective treatment in 28 cases (87.50%). Conclusion: The clinical application of 5-Fluorouracil combined with dactinomycin in the treatment of invasive hydatidiform mole is obvious, which is of great significance to the prognosis of this type of patients. Therefore, it is worthy of clinical application and promotion.