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目的 :以水溶性高分子材料PEG 4 0 0 0为基质 ,研究山腊梅滴丸的最佳制备工艺条件。方法 :以滴丸的成型率 (% )为筛选指标 ,以冷凝液上部的温度、滴丸滴制过程的滴速及冷却柱高度为考察因素 ,采用正交设计对山腊梅滴丸的制备工艺进行优选。结果 :山腊梅滴丸滴制过程中冷凝液上部的温度应控制在 35～ 4 0℃、滴丸滴制过程的滴速为 5 0～ 6 0滴·min-1、冷却柱高度 10 0cm为宜 ,按此优化条件制备的山腊梅滴丸成型率最高。结论 :为提高山腊梅制剂的稳定性提供参考。
OBJECTIVE: To study the optimum preparation conditions of Shanlai Pills by using water-soluble polymer PEG 4000 as matrix. Methods: Taking the forming rate (%) of dropping pills as the screening index, taking the temperature of the upper part of the condensate, the dripping rate of dropping pills and the height of the cooling column as the investigation factors, Preferred. Results: The temperature of the upper part of the condensate drip dripping system should be controlled at 35 ~ 40 ℃. The drip rate of drip drip dripping process was 50 ~ 60 ml · min-1. The height of the cooling column was 100 cm Appropriate, according to the optimal conditions prepared Shanmei dripping pills forming the highest rate. Conclusion: To provide a reference for improving the stability of Rhodiola.