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目的:采用星点设计-效应面法优化太白楤木总皂苷磷脂复合物(TSAT-PC)的制备工艺,并对其理化性质进行研究。方法:采用溶剂挥发法制备TSAT-PC,单因素试验考察反应溶剂、反应时间、反应温度、投料比、药物浓度对复合率的影响,星点设计-效应面法优化制备工艺,并对形成的磷脂复合物进行理化性质研究。结果:最佳制备工艺条件:反应溶剂反应时间1 h、反应温度45℃、大豆磷脂(SL)与TSAT的投料比3∶1、药物浓度16 mg/m L,复合率可达97.23%,与预测值偏差<5%;IR验证了磷脂复合物的形成,其在正辛醇中的溶解度有了较大提高。结论:采用星点设计-效应面法成功制备了TSAT-PC,改善了脂溶性,为中药制剂的进一步开发利用提供了参考。
OBJECTIVE: To optimize the preparation process of total saponin phospholipid complex (TSAT-PC) by using the star-point design-response surface method and study its physicochemical properties. Methods: TSAT-PC was prepared by solvent evaporation. The effects of reaction solvent, reaction time, reaction temperature, feed ratio and drug concentration on the compounding rate were investigated by single factor experiment. The star point design-response surface method was used to optimize the preparation process. Phospholipid complex physical and chemical properties. Results: The optimal preparation conditions were as follows: the reaction time of reaction solvent was 1 h, the reaction temperature was 45 ℃, the feed ratio of soybean phospholipid (SL) to TSAT was 3:1, the drug concentration was 16 mg / m L and the recombination rate was 97.23% The deviation of predicted value was less than 5%. IR confirmed the formation of phospholipid complex and its solubility in n-octanol had been greatly improved. Conclusion: TSAT-PC was successfully prepared by the method of star-point design-response surface method, which improved the liposolubility and provided a reference for the further development and utilization of traditional Chinese medicine preparations.