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Purpose:To compare the therapeutic effects of different doses of intravenous esomeprazole on treating trauma patients with stress ulcer bleeding.Methods:A total of 102 trauma patients with stress ulcer bleeding were randomly divided into 2 groups:52 patients were assigned to the high-dose group who received 80 mg intravenous esomeprazole,and then 8 mg/h continuous infusion for 3 days;50 patients were assigned to the conventional dose group who received 40 mg intravenous esomeprazole sodium once every 12 h for 72 h.Results:Compared with the conventional dose group,the total efficiency of the high-dose group and conventional dose group was 98.08％ and 86.00％,respectively (p ＜ 0.05),the hemostatic time was 22.10 h ± 5.18 h and 28.27 h ± 5.96 h,respectively (p ＜ 0.05).Conclusion:Both doses of intravenous esomeprazole have good hemostatic effects on stress ulcer bleeding in trauma patients.The high-dose esomeprazole is better for hemostasis.