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目的观察Ｇｒａｖｅｓ’病甲亢患者血清ＴＣ、Ｔｇ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ、ＡｐｏＡＩ、ＡｐｏＢ１００和Ｌｐ（ａ）变化并探讨其可能机制。方法采用配对方法比较Ｃａａｖｅｓ’病甲克患者组（甲亢组）和正常对照（正常组）血清ＴＣ、Ｔｇ、ＬＤＬ－Ｃ、ＨＤＬ－Ｃ、ＡｐｏＡＩ、ＡｐｏＢ１００和Ｌｐ（ａ）差异。结果甲亢组较正常组血清ＴＣ明显降低，有高度显著性差异，ｐ＜ ０．０１；甲亢组较正常血清 Ｔｇ、ＬＤＬ－ Ｃ、ＨＤＬ－ Ｃ、ＡｐｏＡＩ、ＡｐｏＢ１００降低，均有高度显著性差异，ｐ＜０．０１；甲亢组较正常血清Ｌｐ（ａ）降低，但无显著性差异，ｐ＜０．０１。结论（１）Ｇｒａｗｅｓ’病甲亢病人血清ＴＣ、Ｔｇ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ、ＡｐｏＡ、ＡｐｏＢ１００均降低，以ＴＣ更明显；（２）尽管甲亢病人血清ＨＤＬ－Ｃ、ＡｐｏＡ１水平降低，但与动脉粥样硬化相关的ＴＣ、Ｔｇ、ＬＤＬ－Ｃ、ＡｐｏＡＩ、ＡｐｏＢ１００也同步降低。因此，我们是否可以推测对于肥胖伴高脂血症，尤其是Ｔ４偏低的病人是否可使用Ｔ４减肥同时降低高脂血症；（３）甲亢病人血清Ｌｐ（ａ）虽有轻度降低，但进一研究甲亢病人的Ｌｐ（ａ）变化及其机理是必要的。
Objective To observe the changes of serum TC, Tg, HDL-C, LDL-C, ApoAI, ApoB100 and Lp (a) in Graves’ patients with hyperthyroidism and to explore its possible mechanism. Methods The paired methods were used to compare the differences of serum TC, Tg, LDL-C, HDL-C, ApoAI, ApoB100 and Lp (a) between caesarean section patients and normal controls (normal group). Results Serum TC of hyperthyroidism group was significantly lower than that of the normal group (p <0.01). There was a highly significant difference between the hyperthyroidism group and the normal serum Tg, LDL-C, HDL-C, ApoAI and ApoB100, p <0.01; hyperthyroidism group than the normal serum Lp (a) decreased, but no significant difference, p <0.01. Conclusions (1) The levels of TC, Tg, HDL-C, LDL-C, ApoA and ApoB100 in patients with Graves ’disease are significantly lower than those in patients with Graves’ disease. (2) Although the serum levels of HDL-C and ApoA1 are decreased in patients with hyperthyroidism, Atherosclerosis-related TC, Tg, LDL-C, ApoAI, ApoB100 decreased simultaneously. Therefore, we can speculate whether obesity with hyperlipidemia, especially in patients with low T4 can use T4 to lose weight while reducing hyperlipidemia; (3) patients with hyperthyroidism serum Lp (a) although slightly reduced, It is necessary to study the changes of Lp (a) and its mechanism in patients with hyperthyroidism.