本文结合文献复习报道5例经免疫电泳证实为巨球蛋白血症。其中3例有神经系统改变,3例有骨质的变化。本文重点讨论了本病的诊断、神经系统和骨质变化的临床特点。骨质改变在本病不罕见,不能做为与多发性骨髓瘤的鉴别要点。诊断本病需做血清IgM和免疫电泳的测定,再结合血液学、病理组织学以及临床做出综合判断。 This article combined with the literature review reported in 5 cases confirmed by immunoelectrophoresis macroglobulinemia. Three of them had neurological changes and three had bone changes. This article focuses on the diagnosis of the disease, the clinical features of the nervous system and bone changes. Bone changes in the disease is not uncommon, can not be used as the identification of multiple myeloma points. Diagnosis of the disease need to do serum IgM and immunoelectrophoresis determination, combined with hematology, histopathology and clinical to make a comprehensive judgment.